US 421 Traffic and Road Conditions

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Current US 421 Traffic Conditions

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US 421 Traffic Delays

Indiana US 421
274mi From Michigan City to Madison
4 hours 51 mins travel time instead of 4 hours 19 mins
32 minutes Delay
Kentucky US 421
245mi From Milton to Cranks
5 hours 5 mins travel time instead of 4 hours 20 mins
45 minutes Delay
North Carolina US 421
343mi From Vilas to Kure Beach
6 hours 0 mins travel time instead of 5 hours 31 mins
29 minutes Delay
Tennessee US 421
250mi From to
4 hours 6 mins travel time instead of 3 hours 41 mins
25 minutes Delay
Virginia US 421
59.4mi From Pennington Gap to Bristol
1 hour 38 mins travel time instead of 1 hour 18 mins
20 minutes Delay

US 421 Live Traffic Cams

US 76/421 at Cape Fear Memorial Bridge (East side) Traffic Camera

North Carolina US 76/421 at Cape Fear Memorial Bridge (East side) Traffic Cam

Cape Fear Mem Bridge - West Traffic Camera

North Carolina Cape Fear Mem Bridge - West Traffic Cam

I-40 at US 421 S - Mile Marker 223 Traffic Camera

North Carolina I-40 at US 421 S Traffic Cam

Live Reports from the DOT's Twitter

9 hours ago
TrafficWise

I-74 EB: Roadwork from W 750 N (1m W of Greensburg) to US 421; OLD US 421 (Greensburg) (MM 128 to MM 132, ). Mobile maintenance operations. https://t.co/Ai1tT6btAC
1 day ago
TrafficWise

US 20 WB: Road maintenance operations at US 421 (MM 40, Michigan City). https://t.co/yALZEzJyEr
1 day ago
TrafficWise

I-94 EB: Road maintenance operations from IN 249 (Portage) to US 421 (near Michigan City) (MM 19 to MM 34.6, ). https://t.co/8sT2P7RgPz

DOT Accident and Construction Reports

Accident on Old US 421 from Post Rd/Exit 96 (I-74) to I-465/Exit 94B (I-74).

TYPE: Accident Serious

US 421 News Reports

2 dead, 1 hurt in crash on Highway 421 in Winston-Salem
- US 421
- source: Bing
- 29 views
- Oct 19, 2026 09:02am
421

2 dead, 1 hurt in crash on Highway 421 in Winston-Salem ... Read More
Police: Hwy. 421 crash kills two in Winston-Salem on Sunday
- North Carolina
- US 421
- source: Bing
- 26 views
- Oct 19, 2026 04:14am
421

Two people were killed, and a third was injured on Sunday in a car crash on U.S. Highway 421. Read More
Vehicle crash closes part of US 421 south in Winston-Salem: Police
- Silas Creek Pkwy
- source: Bing
- 19 views
- Oct 18, 2026 12:58pm
Southbound U.S. 421 traffic is being diverted onto eastbound I-40 near Silas Creek Parkway, according to an incident alert. Read More
Volunteers sought for Halloween roadside cleanup in New Hanover County
- North Carolina
- US 421
- source: Bing
- 29 views
- Oct 14, 2026 05:42am
421

The Plastic Ocean Project and its student chapter at the University of North Carolina Wilmington are asking students and community members to help pick up litter along a local highway. Read More
Watauga County Fatal Collision on US 421 at Mabel School Road
- Us-421 S
- source: Bing
- 34 views
- Sep 28, 2026 03:00am
On Monday, September 28th at approximately 09:59 a.m., The North Carolina State Highway Patrol responded to and investigated a fatal collision on US 421 at Mabel School Road, in Watauga County. A Ford ... Read More

More results in our US 421 Archives